Structural Insights into the Mechanism of Chiral Recognition and Chirality Transfer in Host-Guest Assemblies at the Liquid-Solid Interface

Understanding structure-efficiency relationships in chiral recognition and chirality transfer constitutes an important step toward the rational design of improved chiral probes and chirality auxiliaries or inducers. Recently discovered enantioselective host-guest adsorption opened a new pathway toward the enantioselective reconstruction of on-surface monolayers. In this study, we explored the importance of size matching between host cavity and chiral guest for the efficiency of chiral recognition and subsequent chirality induction in the initially racemic host.