Structural pore models are generated for Vpu1-32WT from HIV-1 as well as for three mutants W23L, S24L and R31V. A computational methodology is employed which samples the whole conformational space of the pentameric assemblies of Vpu. The analysis of the related energy landscape reveals a small set of reasonable pore models, which are thoroughly investigated regarding their structural properties as well as their putative stability under native-like conditions. The models are also discussed in respect of earlier experimental Wndings about their channel activities. The study proposes functional pores reXecting the experimentally found conductance states of Vpu and its mutants.