Structural and cognitive deficits in chronic carbon monoxide intoxication: A voxel-based morphometry study

Hsiu Ling Chen, Pei Chin Chen, Cheng Hsien Lu, Nai Wen Hsu, Kun Hsien Chou, Ching Po Lin, Re Wen Wu, Shau Hsuan Li, Yu Fan Cheng, Wei Che Lin*


研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)


Background: Patients with carbon monoxide (CO) intoxication may develop ongoing neurological and psychiatric symptoms that ebb and flow, a condition often called delayed encephalopathy (DE). The association between morphologic changes in the brain and neuropsychological deficits in DE is poorly understood.Methods: Magnetic resonance imaging and neuropsychological tests were conducted on 11 CO patients with DE, 11 patients without DE, and 15 age-, sex-, and education-matched healthy subjects. Differences in gray matter volume (GMV) between the subgroups were assessed and further correlated with diminished cognitive functioning.Results: As a group, the patients had lower regional GMV compared to controls in the following regions: basal ganglia, left claustrum, right amygdala, left hippocampus, parietal lobes, and left frontal lobe. The reduced GMV in the bilateral basal ganglia, left post-central gyrus, and left hippocampus correlated with decreased perceptual organization and processing speed function. Those CO patients characterized by DE patients had a lower GMV in the left anterior cingulate and right amygdala, as well as lower levels of cognitive function, than the non-DE patients.Conclusions: Patients with CO intoxication in the chronic stage showed a worse cognitive and morphologic outcome, especially those with DE. This study provides additional evidence of gray matter structural abnormalities in the pathophysiology of DE in chronic CO intoxicated patients.

期刊BMC Neurology
出版狀態Published - 1 10月 2013


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