Strategies in aliphatic polyester synthesis for biomaterial and drug delivery applications

Angela L. Silvers, Chia Chih Chang, Bryan Parrish, Todd Emrick

研究成果: Chapter同行評審

7 引文 斯高帕斯(Scopus)

摘要

Aliphatic polyesters are among the most important class of synthetic polymers for biomedical applications due to their biodegradability and generally high biocompatibility. However, conventional aliphatic polyesters are semi-crystalline, hydrophobic solids lacking in functionality, such that strategic tailoring of their structure and functionality could expand their application base considerably. Numeorus synthetic methods have been examined for introducing functionality to aliphatic polyesters. This chapter will describe a number of reported methods, focusing on examples of ring-opening polymerization (ROP) of functionalized lactones, and post-polymerization functionalization that affords well-defined materials with high degrees of functionality and narrow polydispersities. In addition, new developments in biocompatible ROP catalysts as well as novel polyester architectures, such as cyclic polymers, will be discussed.

原文English
主出版物標題Degradable Polymers and Materials
主出版物子標題Principles and Practice (2nd Edition)
發行者American Chemical Society
頁面237-254
頁數18
ISBN(列印)9780841228221
DOIs
出版狀態Published - 14 十一月 2012

出版系列

名字ACS Symposium Series
1114
ISSN(列印)0097-6156
ISSN(電子)1947-5918

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