Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study

Stylianos Pikis, Georgios Mantziaris, Yavuz Samanci, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M.N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Cheng chia Lee, Huai che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Jason Sheehan*


研究成果: Article同行評審


Background: The initial management of asymptomatic, incidentally discovered, cavernous sinus (CS) meningiomas remains incompletely defined. This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for patients presenting with an asymptomatic CS meningioma. Methods: This is an international, retrospective study included patients treated with upfront SRS for an asymptomatic CS meningioma. Local tumor control, tumor and SRS-related complications, and the development of new neurologic deficits after SRS were evaluated. Results: A total of 37 patients (29 men; mean ± SD age: 55.05 ± 11.56 years) treated with upfront SRS for an asymptomatic, CS meningioma were included in the study. The mean ± SD margin dose was 12.27 ± 2.3 Gy. The median clinical and radiological follow-up periods were 66 (IQR 84) and 72 (IQR 84) months, respectively. At the last follow-up, tumor regression and stability were noted in 19 (51.35%) and 18 (48.65%) of CS meningiomas, respectively. SRS-related complications occurred in 2 patients (5.4%) and were managed conservatively. Conclusions: Upfront SRS is a safe and effective treatment option for asymptomatic CS meningiomas. SRS may be considered at the time of initial diagnosis of a CS meningioma. If observation is the initial management chosen, SRS should be recommended when CS meningioma growth is documented on follow-up imaging.

頁(從 - 到)e675-e680
期刊World Neurosurgery
出版狀態Published - 2月 2022


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