Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study

Stylianos Pikis; Georgios Mantziaris; Yavuz Samanci; Selcuk Peker; Ahmed M. Nabeel; Wael A. Reda; Sameh R. Tawadros; Amr M.N. El-Shehaby; Khaled Abdelkarim; Reem M. Emad; Cheng chia Lee; Huai che Yang; Roman Liscak; Jaromir Hanuska; Roberto Martinez Alvarez; Nuria Martinez Moreno; Manjul Tripathi; Herwin Speckter; Camilo Albert; Jason Sheehan

doi:10.1016/j.wneu.2021.11.037

Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study

Stylianos Pikis, Georgios Mantziaris, Yavuz Samanci, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Amr M.N. El-Shehaby, Khaled Abdelkarim, Reem M. Emad, Cheng chia Lee, Huai che Yang, Roman Liscak, Jaromir Hanuska, Roberto Martinez Alvarez, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Jason Sheehan^*

^*此作品的通信作者

醫學系外科學科

研究成果: Article › 同行評審

摘要

Background: The initial management of asymptomatic, incidentally discovered, cavernous sinus (CS) meningiomas remains incompletely defined. This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for patients presenting with an asymptomatic CS meningioma. Methods: This is an international, retrospective study included patients treated with upfront SRS for an asymptomatic CS meningioma. Local tumor control, tumor and SRS-related complications, and the development of new neurologic deficits after SRS were evaluated. Results: A total of 37 patients (29 men; mean ± SD age: 55.05 ± 11.56 years) treated with upfront SRS for an asymptomatic, CS meningioma were included in the study. The mean ± SD margin dose was 12.27 ± 2.3 Gy. The median clinical and radiological follow-up periods were 66 (IQR 84) and 72 (IQR 84) months, respectively. At the last follow-up, tumor regression and stability were noted in 19 (51.35%) and 18 (48.65%) of CS meningiomas, respectively. SRS-related complications occurred in 2 patients (5.4%) and were managed conservatively. Conclusions: Upfront SRS is a safe and effective treatment option for asymptomatic CS meningiomas. SRS may be considered at the time of initial diagnosis of a CS meningioma. If observation is the initial management chosen, SRS should be recommended when CS meningioma growth is documented on follow-up imaging.

原文	English
頁（從 - 到）	e675-e680
期刊	World Neurosurgery
卷	158
DOIs	https://doi.org/10.1016/j.wneu.2021.11.037
出版狀態	Published - 2月 2022

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10.1016/j.wneu.2021.11.037

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Pikis, S., Mantziaris, G., Samanci, Y., Peker, S., Nabeel, A. M., Reda, W. A., Tawadros, S. R., El-Shehaby, A. M. N., Abdelkarim, K., Emad, R. M., Lee, C. C., Yang, H. C., Liscak, R., Hanuska, J., Alvarez, R. M., Moreno, N. M., Tripathi, M., Speckter, H., Albert, C., & Sheehan, J. (2022). Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study. World Neurosurgery, 158, e675-e680. https://doi.org/10.1016/j.wneu.2021.11.037

@article{2b5d2a08cc464d259582de5243a4267f,

title = "Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study",

abstract = "Background: The initial management of asymptomatic, incidentally discovered, cavernous sinus (CS) meningiomas remains incompletely defined. This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for patients presenting with an asymptomatic CS meningioma. Methods: This is an international, retrospective study included patients treated with upfront SRS for an asymptomatic CS meningioma. Local tumor control, tumor and SRS-related complications, and the development of new neurologic deficits after SRS were evaluated. Results: A total of 37 patients (29 men; mean ± SD age: 55.05 ± 11.56 years) treated with upfront SRS for an asymptomatic, CS meningioma were included in the study. The mean ± SD margin dose was 12.27 ± 2.3 Gy. The median clinical and radiological follow-up periods were 66 (IQR 84) and 72 (IQR 84) months, respectively. At the last follow-up, tumor regression and stability were noted in 19 (51.35%) and 18 (48.65%) of CS meningiomas, respectively. SRS-related complications occurred in 2 patients (5.4%) and were managed conservatively. Conclusions: Upfront SRS is a safe and effective treatment option for asymptomatic CS meningiomas. SRS may be considered at the time of initial diagnosis of a CS meningioma. If observation is the initial management chosen, SRS should be recommended when CS meningioma growth is documented on follow-up imaging.",

keywords = "Asymptomatic, Cavernous sinus, Meningioma, Radiosurgery",

author = "Stylianos Pikis and Georgios Mantziaris and Yavuz Samanci and Selcuk Peker and Nabeel, {Ahmed M.} and Reda, {Wael A.} and Tawadros, {Sameh R.} and El-Shehaby, {Amr M.N.} and Khaled Abdelkarim and Emad, {Reem M.} and Lee, {Cheng chia} and Yang, {Huai che} and Roman Liscak and Jaromir Hanuska and Alvarez, {Roberto Martinez} and Moreno, {Nuria Martinez} and Manjul Tripathi and Herwin Speckter and Camilo Albert and Jason Sheehan",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = feb,

doi = "10.1016/j.wneu.2021.11.037",

language = "English",

volume = "158",

pages = "e675--e680",

journal = "World Neurosurgery",

issn = "1878-8750",

publisher = "Elsevier Inc.",

}

Pikis, S, Mantziaris, G, Samanci, Y, Peker, S, Nabeel, AM, Reda, WA, Tawadros, SR, El-Shehaby, AMN, Abdelkarim, K, Emad, RM, Lee, CC, Yang, HC, Liscak, R, Hanuska, J, Alvarez, RM, Moreno, NM, Tripathi, M, Speckter, H, Albert, C & Sheehan, J 2022, 'Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study', World Neurosurgery, 卷 158, 頁 e675-e680. https://doi.org/10.1016/j.wneu.2021.11.037

TY - JOUR

T1 - Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas

T2 - A Multi-institutional Study

AU - Pikis, Stylianos

AU - Mantziaris, Georgios

AU - Samanci, Yavuz

AU - Peker, Selcuk

AU - Nabeel, Ahmed M.

AU - Reda, Wael A.

AU - Tawadros, Sameh R.

AU - El-Shehaby, Amr M.N.

AU - Abdelkarim, Khaled

AU - Emad, Reem M.

AU - Lee, Cheng chia

AU - Yang, Huai che

AU - Liscak, Roman

AU - Hanuska, Jaromir

AU - Alvarez, Roberto Martinez

AU - Moreno, Nuria Martinez

AU - Tripathi, Manjul

AU - Speckter, Herwin

AU - Albert, Camilo

AU - Sheehan, Jason

PY - 2022/2

Y1 - 2022/2

N2 - Background: The initial management of asymptomatic, incidentally discovered, cavernous sinus (CS) meningiomas remains incompletely defined. This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for patients presenting with an asymptomatic CS meningioma. Methods: This is an international, retrospective study included patients treated with upfront SRS for an asymptomatic CS meningioma. Local tumor control, tumor and SRS-related complications, and the development of new neurologic deficits after SRS were evaluated. Results: A total of 37 patients (29 men; mean ± SD age: 55.05 ± 11.56 years) treated with upfront SRS for an asymptomatic, CS meningioma were included in the study. The mean ± SD margin dose was 12.27 ± 2.3 Gy. The median clinical and radiological follow-up periods were 66 (IQR 84) and 72 (IQR 84) months, respectively. At the last follow-up, tumor regression and stability were noted in 19 (51.35%) and 18 (48.65%) of CS meningiomas, respectively. SRS-related complications occurred in 2 patients (5.4%) and were managed conservatively. Conclusions: Upfront SRS is a safe and effective treatment option for asymptomatic CS meningiomas. SRS may be considered at the time of initial diagnosis of a CS meningioma. If observation is the initial management chosen, SRS should be recommended when CS meningioma growth is documented on follow-up imaging.

AB - Background: The initial management of asymptomatic, incidentally discovered, cavernous sinus (CS) meningiomas remains incompletely defined. This study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) for patients presenting with an asymptomatic CS meningioma. Methods: This is an international, retrospective study included patients treated with upfront SRS for an asymptomatic CS meningioma. Local tumor control, tumor and SRS-related complications, and the development of new neurologic deficits after SRS were evaluated. Results: A total of 37 patients (29 men; mean ± SD age: 55.05 ± 11.56 years) treated with upfront SRS for an asymptomatic, CS meningioma were included in the study. The mean ± SD margin dose was 12.27 ± 2.3 Gy. The median clinical and radiological follow-up periods were 66 (IQR 84) and 72 (IQR 84) months, respectively. At the last follow-up, tumor regression and stability were noted in 19 (51.35%) and 18 (48.65%) of CS meningiomas, respectively. SRS-related complications occurred in 2 patients (5.4%) and were managed conservatively. Conclusions: Upfront SRS is a safe and effective treatment option for asymptomatic CS meningiomas. SRS may be considered at the time of initial diagnosis of a CS meningioma. If observation is the initial management chosen, SRS should be recommended when CS meningioma growth is documented on follow-up imaging.

KW - Asymptomatic

KW - Cavernous sinus

KW - Meningioma

KW - Radiosurgery

UR - http://www.scopus.com/inward/record.url?scp=85120431806&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2021.11.037

DO - 10.1016/j.wneu.2021.11.037

M3 - Article

C2 - 34785361

AN - SCOPUS:85120431806

SN - 1878-8750

VL - 158

SP - e675-e680

JO - World Neurosurgery

JF - World Neurosurgery

ER -

Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study

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