Statins reduces the risk of dementia in patients with late-onset depression: A retrospective cohort study

Ya Hsu Yang, Hao Wei Teng, Yen Ting Lai, Szu Yuan Li, Chih Ching Lin, Albert C. Yang, Hsiang Lin Chan, Yi Hsuan Hsieh, Chiao Fan Lin, Fu Ying Hsu, Chih Kuang Liu, Wen Sheng Liu

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Objective Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia. The present study was conducted to assess whether statins can reduce the risk of dementia in these patients. Methods We used the data from National Health Insurance of Taiwan during 1996-2009. Standardized Incidence Ratios (SIRs) were calculated for LOD and subsequent dementia. The criteria for LOD diagnoses included age ≥65 years, diagnosis of depression after 65 years of age, at least three service claims, and treatment with antidepressants. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to select matching patients for validation studies. Kaplan-Meier curve estimate was used to measure the group of patients with dementia living after diagnosis of LOD. Results Totally 45,973 patients aged ≥65 years were enrolled. The prevalence of LOD was 12.9% (5,952/45,973). Patients with LOD showed to have a higher incidence of subsequent dementia compared with those without LOD (Odds Ratio: 2.785; 95% CI 2.619-2.958). Among patients with LOD, lipid lowering agent (LLA) users (for at least 3 months) had lower incidence of subsequent dementia than non-users (Hazard Ratio = 0.781, 95% CI 0.685-0.891). Nevertheless, only statins users showed to have reduced risk of dementia (Hazard Ratio = 0.674, 95% CI 0.547-0.832) while other LLAs did not, which was further validated by Kaplan-Meier estimates after we used the propensity scores with the one-to-one nearest-neighbor matching model to control the confounding factors. Conclusions Statins may reduce the risk of subsequent dementia in patients with LOD.

原文English
文章編號e0137914
期刊PLoS ONE
10
發行號9
DOIs
出版狀態Published - 18 9月 2015

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