TY - JOUR
T1 - State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development
AU - Poltronieri, Palmiro
AU - Sun, Binlian
AU - Huang, Kai Yao
AU - Chang, Tzu Hao
AU - Lee, Tzong Yi
N1 - Publisher Copyright:
Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2018
Y1 - 2018
N2 - BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.
AB - BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.
KW - Human Papilloma Virus (HPV)
KW - immunity
KW - microRNAs
KW - oncogenesis
KW - seed sequence complementarity
KW - translation repression.
UR - http://www.scopus.com/inward/record.url?scp=85055901715&partnerID=8YFLogxK
U2 - 10.2174/2211536607666180328115155
DO - 10.2174/2211536607666180328115155
M3 - Review article
C2 - 29595120
AN - SCOPUS:85055901715
SN - 2211-5374
VL - 7
SP - 85
EP - 91
JO - MicroRNA (Shariqah, United Arab Emirates)
JF - MicroRNA (Shariqah, United Arab Emirates)
IS - 2
ER -