sRNAMap: Genomic maps for small non-coding RNAs, their regulators and their targets in microbial genomes

Hsi Yuan Huang, Heng Yi Chang, Chih Hung Chou, Ching-Ping Tseng, Shinn-Ying Ho, Chi Dung Yang, Yih Wei Ju, Hsien Da Huang*

*此作品的通信作者

研究成果: Article同行評審

74 引文 斯高帕斯(Scopus)

摘要

Small non-coding RNAs (sRNAs) carry out a variety of biological functions and affect protein synthesis and protein activities in prokaryotes. Recently, numerous sRNAs and their targets were identified in Escherichia coli and in other bacteria. It is crucial to have a comprehensive resource concerning the annotation of small non-coding RNAs in microbial genomes. This work presents an integrated database, namely sRNAMap, to collect the sRNA genes, the transcriptional regulators of sRNAs and the sRNA target genes by integrating a variety of biological databases and by surveying literature. In this resource, we collected 397 sRNAs, 62 regulators/sRNAs and 60 sRNAs/targets in 70 microbial genomes. Additionally, more valuable information of the sRNAs, such as the secondary structure of sRNAs, the expressed conditions of sRNAs, the expression profiles of sRNAs, the transcriptional start sites of sRNAs and the cross-links to other biological databases, are provided for further investigation. Besides, various textual and graphical interfaces were designed and implemented to facilitate the data access in sRNAMap. sRNAMap is available at http://sRNAMap.mbc.nctu.edu.tw/.

原文English
頁(從 - 到)D150-D154
期刊Nucleic acids research
37
發行號SUPPL. 1
DOIs
出版狀態Published - 2009

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