@article{98bdd789da2d465daaa5c44eb35849a8,
title = "Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives",
abstract = "Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 °C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex.",
keywords = "DNA triplex, Indolo[2,1-b]quinazolin-6,12-dione, Thermal denaturation, Triplex stabilizing agents, Tryptanthrin",
author = "Chen, {Grace Shiahuy} and Bhagwat, {Bhalchandra V.} and Liao, {Pei Yin} and Chen, {Hui Ting} and Lin, {Shwu Bin} and Chern, {Ji Wang}",
note = "Funding Information: This work was supported in part by the National Science Council of the Republic of China, Taiwan (NSC92-3112-B-002-045 and NSC93-2320-B002-133). We thank The National Center for High-Performance Computing, Taiwan, for computer resources.",
year = "2007",
month = mar,
day = "15",
doi = "10.1016/j.bmcl.2006.12.079",
language = "English",
volume = "17",
pages = "1769--1772",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "6",
}