Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel

Heng Tsan Su; May Jywan Tsai; Gao Fong Chang; Chen Hsiung Hung; Hung Cheng Lin; Che Yeu Chou; Ding Wen Huang; Che Chang Liang; Yu Chao Lin; Hsin Fei Meng; Hsiao Wen Zan; Sheng Fu Horng; Dann Ying Liou; Henrich Cheng

doi:10.1016/j.orgel.2015.07.040

Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel

Heng Tsan Su, May Jywan Tsai, Gao Fong Chang, Chen Hsiung Hung, Hung Cheng Lin, Che Yeu Chou, Ding Wen Huang, Che Chang Liang, Yu Chao Lin, Hsin Fei Meng^*, Hsiao Wen Zan, Sheng Fu Horng, Dann Ying Liou, Henrich Cheng

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5 引文斯高帕斯（Scopus）

摘要

A tip-shaped zinc ion solid-state sensor is made by two parallel optical fibers embedded closely in a sensing hydrogel film. The film is made of poly(2-hydroxyethyl methacrylate) (poly HEMA)hydrogel mixed with the selective fluorescent probe meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl₂) with weight ratio of 0.025 wt%. A 405 nm laser output is sent from one fiber and the 622 nm fluorescence of the doped hydrogel is collected by the second fiber. Each fiber diameter is 370 μm (core is 300 μm), whose sum is roughly the tip diameter. The 0.4 cm by 0.5 cm tip has real-time response for zinc ion concentration over 10^-6 M, with marginal signal for 10^-7 M. The tip is inserted inside an oyster and successfully detects the zinc ions, showing that the sensor works in complex body fluid and tolerates certain mechanical stress. To show the potential application for medicine, the sensing film is applied for primary neuronal cultures. We report for the first time zinc ions release at concentration levels 10^-6-10^-7 M to the medium under stress conditions of ischemia, inflammation, and intoxication. Furthermore, this correlates with the zinc levels detected by biochemical assay. Such sensing tip has great potential for biomedical monitoring ex vivo or in vivo.

原文	English
頁（從 - 到）	429-438
頁數	10
期刊	Organic Electronics
卷	26
DOIs	https://doi.org/10.1016/j.orgel.2015.07.040
出版狀態	Published - 26 8月 2015

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10.1016/j.orgel.2015.07.040

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Su, H. T., Tsai, M. J., Chang, G. F., Hung, C. H., Lin, H. C., Chou, C. Y., Huang, D. W., Liang, C. C., Lin, Y. C., Meng, H. F., Zan, H. W., Horng, S. F., Liou, D. Y., & Cheng, H. (2015). Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel. Organic Electronics, 26, 429-438. https://doi.org/10.1016/j.orgel.2015.07.040

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title = "Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel",

abstract = "A tip-shaped zinc ion solid-state sensor is made by two parallel optical fibers embedded closely in a sensing hydrogel film. The film is made of poly(2-hydroxyethyl methacrylate) (poly HEMA)hydrogel mixed with the selective fluorescent probe meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl2) with weight ratio of 0.025 wt%. A 405 nm laser output is sent from one fiber and the 622 nm fluorescence of the doped hydrogel is collected by the second fiber. Each fiber diameter is 370 μm (core is 300 μm), whose sum is roughly the tip diameter. The 0.4 cm by 0.5 cm tip has real-time response for zinc ion concentration over 10-6 M, with marginal signal for 10-7 M. The tip is inserted inside an oyster and successfully detects the zinc ions, showing that the sensor works in complex body fluid and tolerates certain mechanical stress. To show the potential application for medicine, the sensing film is applied for primary neuronal cultures. We report for the first time zinc ions release at concentration levels 10-6-10-7 M to the medium under stress conditions of ischemia, inflammation, and intoxication. Furthermore, this correlates with the zinc levels detected by biochemical assay. Such sensing tip has great potential for biomedical monitoring ex vivo or in vivo.",

keywords = "Double fibers, Neuronal cultures, Sensing tip, Solid-state, Zinc ion",

author = "Su, {Heng Tsan} and Tsai, {May Jywan} and Chang, {Gao Fong} and Hung, {Chen Hsiung} and Lin, {Hung Cheng} and Chou, {Che Yeu} and Huang, {Ding Wen} and Liang, {Che Chang} and Lin, {Yu Chao} and Meng, {Hsin Fei} and Zan, {Hsiao Wen} and Horng, {Sheng Fu} and Liou, {Dann Ying} and Henrich Cheng",

year = "2015",

month = aug,

day = "26",

doi = "10.1016/j.orgel.2015.07.040",

language = "English",

volume = "26",

pages = "429--438",

journal = "Organic Electronics",

issn = "1566-1199",

publisher = "Elsevier B.V.",

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T1 - Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel

AU - Su, Heng Tsan

AU - Tsai, May Jywan

AU - Chang, Gao Fong

AU - Hung, Chen Hsiung

AU - Lin, Hung Cheng

AU - Chou, Che Yeu

AU - Huang, Ding Wen

AU - Liang, Che Chang

AU - Lin, Yu Chao

AU - Meng, Hsin Fei

AU - Zan, Hsiao Wen

AU - Horng, Sheng Fu

AU - Liou, Dann Ying

AU - Cheng, Henrich

PY - 2015/8/26

Y1 - 2015/8/26

N2 - A tip-shaped zinc ion solid-state sensor is made by two parallel optical fibers embedded closely in a sensing hydrogel film. The film is made of poly(2-hydroxyethyl methacrylate) (poly HEMA)hydrogel mixed with the selective fluorescent probe meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl2) with weight ratio of 0.025 wt%. A 405 nm laser output is sent from one fiber and the 622 nm fluorescence of the doped hydrogel is collected by the second fiber. Each fiber diameter is 370 μm (core is 300 μm), whose sum is roughly the tip diameter. The 0.4 cm by 0.5 cm tip has real-time response for zinc ion concentration over 10-6 M, with marginal signal for 10-7 M. The tip is inserted inside an oyster and successfully detects the zinc ions, showing that the sensor works in complex body fluid and tolerates certain mechanical stress. To show the potential application for medicine, the sensing film is applied for primary neuronal cultures. We report for the first time zinc ions release at concentration levels 10-6-10-7 M to the medium under stress conditions of ischemia, inflammation, and intoxication. Furthermore, this correlates with the zinc levels detected by biochemical assay. Such sensing tip has great potential for biomedical monitoring ex vivo or in vivo.

AB - A tip-shaped zinc ion solid-state sensor is made by two parallel optical fibers embedded closely in a sensing hydrogel film. The film is made of poly(2-hydroxyethyl methacrylate) (poly HEMA)hydrogel mixed with the selective fluorescent probe meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl2) with weight ratio of 0.025 wt%. A 405 nm laser output is sent from one fiber and the 622 nm fluorescence of the doped hydrogel is collected by the second fiber. Each fiber diameter is 370 μm (core is 300 μm), whose sum is roughly the tip diameter. The 0.4 cm by 0.5 cm tip has real-time response for zinc ion concentration over 10-6 M, with marginal signal for 10-7 M. The tip is inserted inside an oyster and successfully detects the zinc ions, showing that the sensor works in complex body fluid and tolerates certain mechanical stress. To show the potential application for medicine, the sensing film is applied for primary neuronal cultures. We report for the first time zinc ions release at concentration levels 10-6-10-7 M to the medium under stress conditions of ischemia, inflammation, and intoxication. Furthermore, this correlates with the zinc levels detected by biochemical assay. Such sensing tip has great potential for biomedical monitoring ex vivo or in vivo.

KW - Double fibers

KW - Neuronal cultures

KW - Sensing tip

KW - Solid-state

KW - Zinc ion

UR - http://www.scopus.com/inward/record.url?scp=84940192868&partnerID=8YFLogxK

U2 - 10.1016/j.orgel.2015.07.040

DO - 10.1016/j.orgel.2015.07.040

M3 - Article

AN - SCOPUS:84940192868

SN - 1566-1199

VL - 26

SP - 429

EP - 438

JO - Organic Electronics

JF - Organic Electronics

ER -

Solid-state sensing tip for zinc ion with double parallel optical fibers embedded in fluorescent hydrogel

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