Simple, realistic models of complex biological processes: Positive feedback and bistability in a cell fate switch and a cell cycle oscillator

James E. Ferrell*, Joseph R. Pomerening, Sun Young Kim, Nikki B. Trunnell, Wen Xiong, Chi Ying Frederick Huang, Eric M. Machleder

*此作品的通信作者

研究成果: Review article同行評審

90 引文 斯高帕斯(Scopus)

摘要

Here we review some of our work over the last decade on Xenopus oocyte maturation, a cell fate switch, and the Xenopus embryonic cell cycle, a highly dynamical process. Our approach has been to start with wiring diagrams for the regulatory networks that underpin the processes; carry out quantitative experiments to describe the response functions for individual legs of the networks; and then construct simple analytical models based on chemical kinetic theory and the graphical rate-balance formalism. These studies support the view that the all-or-none, irreversible nature of oocyte maturation arises from a saddle-node bifurcation in the regulatory system that drives the process, and that the clock-like oscillations of the embryo are built upon a hysteretic switch with two saddle-node bifurcations. We believe that this type of reductionistic systems biology holds great promise for understanding complicated biochemical processes in simpler terms.

原文English
頁(從 - 到)3999-4005
頁數7
期刊FEBS Letters
583
發行號24
DOIs
出版狀態Published - 17 12月 2009

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