Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Vijayasimha Molakaseema; Anand Selvaraj; Hui Ting Chen; Yen Wei Chen; Yi Chang Liu; Chai Lin Kao

doi:10.1021/acs.joc.1c01455

Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Vijayasimha Molakaseema, Anand Selvaraj, Hui Ting Chen, Yen Wei Chen, Yi Chang Liu^*, Chai Lin Kao^*

^*此作品的通信作者

藥學系

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4 引文斯高帕斯（Scopus）

摘要

A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

原文	English
頁（從 - 到）	1-9
頁數	9
期刊	Journal of Organic Chemistry
卷	87
發行號	1
DOIs	https://doi.org/10.1021/acs.joc.1c01455
出版狀態	E-pub ahead of print - 10月 2021

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10.1021/acs.joc.1c01455

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abstract = "A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.",

author = "Vijayasimha Molakaseema and Anand Selvaraj and Chen, {Hui Ting} and Chen, {Yen Wei} and Liu, {Yi Chang} and Kao, {Chai Lin}",

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AU - Molakaseema, Vijayasimha

AU - Selvaraj, Anand

AU - Chen, Hui Ting

AU - Chen, Yen Wei

AU - Liu, Yi Chang

AU - Kao, Chai Lin

PY - 2021/10

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AB - A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

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Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

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