Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Vijayasimha Molakaseema, Anand Selvaraj, Hui Ting Chen, Yen Wei Chen, Yi Chang Liu, Chai Lin Kao*

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50-65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

原文English
頁數9
期刊Journal of Organic Chemistry
DOIs
出版狀態E-pub ahead of print - 10月 2021

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