Shared patterns of brain functional connectivity for the comorbidity between migraine and insomnia

Kun Hsien Chou, Chen Yuan Kuo, Chih Sung Liang, Pei Lin Lee, Chia Kuang Tsai, Chia Lin Tsai, Ming Hao Huang, Yi Chih Hsu, Guan Yu Lin, Yu Kai Lin, Ching Po Lin, Fu Chi Yang*

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Migraine is commonly comorbid with insomnia; both disorders are linked to functional disturbance of the default mode network (DMN). Evidence suggests that DMN could be segregated into multiple subnetworks with specific roles that underline different cognitive processes. However, the relative contributions of DMN subnetworks in the comorbidity of migraine and insomnia remain largely unknown. This study sought to identify altered functional connectivity (FC) profiles of DMN subnetworks in the comorbidity of migraine and insomnia. Direct group comparisons with healthy controls, followed by conjunction analyses, were used to identify shared FC alterations of DMN subnetworks. The shared FC changes of the DMN subnetworks in the migraine and insomnia groups were identified in the dorsomedial prefrontal and posteromedial cortex subnetworks. These shared FC changes were primarily associated with motor and somatosensory systems, and consistently found in patients with comorbid migraine and insomnia. Additionally, the magnitude of FC between the posteromedial cortex and postcentral gyrus correlated with insomnia duration in patients with comorbid migraine and insomnia. Our findings point to specific FC alterations of the DMN subnetwork in migraine and insomnia. The shared patterns of FC disturbance may be associated with the underlying mechanisms of the comorbidity of the two disorders.

原文English
文章編號1420
期刊Biomedicines
9
發行號10
DOIs
出版狀態Published - 10月 2021

指紋

深入研究「Shared patterns of brain functional connectivity for the comorbidity between migraine and insomnia」主題。共同形成了獨特的指紋。

引用此