Sensory stimulation-induced neuroprotection in hyperacute phase of ischemic stroke – a multimodal imaging study

Lun De Liao*, Yu Hang Liu, Aishwarya Bandla, Ji Min Ling, Hsin Yi Lai, You Yin Chen, Nitish V. Thakor

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Study of cerebral cortical functions affected by ischemic stroke explicates post-stroke brain plasticity. We report an innovative combination of electrocorticography (ECoG) recordings and functional photoacoustic microscopy (fPAM) imaging to investigate cortical functions after photothrombotic ischemia (PTI) in rat brain, with electrical forepaw stimulation applied as treatment. The cortical functions were assessed over a chosen ischemic region via somatosensoryevoked potential (SSEP), resting-state ECoG signals and evoked hemodynamic response. Two-phased experimental protocols based on sensory stimulation treatment are proposed and performed in this study. In the phase 1, the treatment is applied to the left forepaw, contralateral to the ischemic hemisphere, with 2 mA pulses initiated 0, 1, or 2 hours postischemia to determine optimal onset timing. After determining the optimal time window, in the phase 2, the treatment was delivered unilaterally or bilaterally using 2 or 4 mA pulses for validating if bilateral peripheral electrical stimulation with different current intensities could improve cerebral perfusion and restore cortical neurovascular response. Overall, the results demonstrated that our treatment administered bilaterally at 2 mA within 2 hours of ischemia can promote neuroprotection significantly via reversed cortical functions, suggesting effective recovery.

原文English
主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
發行者Springer Verlag
頁面256-259
頁數4
ISBN(電子)9783319122618
DOIs
出版狀態Published - 2015
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 9 10月 201412 10月 2014

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737
ISSN(電子)1433-9277

Conference

Conference1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家/地區Taiwan
城市Tainan
期間9/10/1412/10/14

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