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Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length
Ta Chun Cheng
, Kuo Hsiang Chuang
, Michael Chen
, Hsin Ell Wang
,
Shey-Cherng Tzou
,
Yu-Cheng Su
, Chih Hung Chuang
, Chien Han Kao
, Bing Mae Chen
, Long Sen Chang
, Steve R. Roffler
*
, Tian Lu Cheng
*
此作品的通信作者
生物科技學系
研究成果
:
Article
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17
引文 斯高帕斯(Scopus)
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Keyphrases
Biological Efficacy
7%
Epitope Masking
14%
Human Serum
7%
Immune Epitope
7%
Immunogenicity
7%
Interferon-α (IFN-α)
35%
Iodine-131 (131I)
7%
Limit of Detection
7%
Mouse Serum
7%
Pegasys
14%
PEGylated
7%
Pegylated Interferon
100%
PEGylated Proteins
7%
PEGylation
14%
Pharmacokinetic Study
7%
Polyethylene Glycol
100%
Polyethylene Glycol Antibodies
100%
Protein Drug
7%
Quantitative Measurement
7%
Radioassay
7%
Sandwich ELISA
64%
Serum Half-life
7%
Immunology and Microbiology
ELISA
33%
ELISA Sandwich
100%
Epitope
33%
Immunity
11%
Immunogenicity
11%
interferon
55%
Intron
11%
Iodine-131
11%
Masking
33%
Peginterferon Alfa-2a
22%
Pegylated Interferon
100%
PEGylation
22%
Pharmacokinetics
11%
Plasma Half Life
11%
Pharmacology, Toxicology and Pharmaceutical Science
ELISA Sandwich
60%
Enzyme-Linked Immunosorbent Assay
20%
Epitope
20%
Immunogenicity
6%
Interferon
33%
Iodine-131
6%
Macrogol
100%
Macrogol Derivative
6%
Peginterferon
100%
Peginterferon Alpha2a
13%
PEGylation
13%
Pharmacokinetics
6%
Potassium 40
6%