Self-assembly of a micelle structure from graft and diblock copolymers: An example of overcoming the limitations of polyions in drug delivery

Chun Liang Lo*, Ko Min Lin, Chun Kai Huang, Ging Ho Hsiue

*此作品的通信作者

研究成果: Article同行評審

59 引文 斯高帕斯(Scopus)

摘要

A novel mixed micelle with a multifunctional core and shell is successfully prepared from a graft copolymer, poly(N-isopropyl acrylamide-co-methacrylic acid)-g-poly(D,L-lactide) (P(NIPAAm-co-MAAc)-g-PLA) and two diblock copolymers, poly(ethylene glycol)-b-poly(D,L-lactide) and poly (2-ethyl-2-oxazoline)-b- poly(D,L-lactide). This nanostructure completely screens the highly negative charges of the graft copolymer and exhibits multifunctionality because it has a specialized core/shell structure. An example of this micelle structure used in intracellular drug delivery demonstrates a strong relationship between drug release and the functionality of the mixed micelle. Additionally, the efficiency of the screening feature is also displayed in the cytotoxicities; mixed micelles exhibit higher drug activity and lower material cytotoxicity than micelles from P(NIPAAm-co-MAAc)-g-PLA ([NIPAAm]/[MAAc]/[PLA] = 84:5.9:2.5 mol/mol) copolymer. This study not only presents a new micelle structure generated using a graft-diblock copolymer system, but also elucidates concepts upon which the preparation of a multifunctional micelle from a graft copolymer with a single (or many) diblock copolymer(s) can be based for applications in drug delivery.

原文English
頁(從 - 到)2309-2316
頁數8
期刊Advanced Functional Materials
16
發行號18
DOIs
出版狀態Published - 4 12月 2006

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