Selective fluorescence turn-off detection of lysine by a curcumin derivative with real sample analysis

Raja Lavanya, Selvam Poovarasan, Venkatesan Srinivasadesikan, Ming chang Lin, Vediappen Padmini*

*此作品的通信作者

研究成果: Article同行評審

摘要

A curcumin-based fluorescence sensor DPT [(2Z,4E,6E)-7-(4-(dimethylamino)phenyl)-3-hydroxy-1-phenylhepta-2,4,6-trien-1-one] was synthesized by a simple synthetic method. The DPT fluorescence sensor selectively detects lysine (Lys) in the presence of other amino acids and metal ions. The lower detection limit of DPT in 94 nM and the binding constant in 5.6 × 107 M−1 in DMSO/H2O (1:9) medium. The binding mechanism involves intramolecular charge transfer (ICT) as confirmed by DFT studies. In addition, DPT and lysine show 1:1 binding stoichiometry. The interaction has been confirmed with 1H NMR. Lysine has been detected in blood and urine samples using real sample analysis.

原文English
文章編號115008
期刊Journal of Photochemistry and Photobiology A: Chemistry
444
DOIs
出版狀態Published - 1 10月 2023

指紋

深入研究「Selective fluorescence turn-off detection of lysine by a curcumin derivative with real sample analysis」主題。共同形成了獨特的指紋。

引用此