Sample preparation for many-reactant bioassay on DMFBs using common dilution operation sharing

Chia Hung Liu, Hao Han Chang, Tung Che Liang, Juinn-Dar Huang

    研究成果: Conference contribution同行評審

    44 引文 斯高帕斯(Scopus)

    摘要

    Sample preparation is an essential processing step in most biochemical applications. Various reactants are mixed together to produce a solution with the target concentration. Since reactants generally take a notable part of the cost in a bioassay, their usage should be minimized whenever possible. In this paper, we propose an algorithm, CoDOS, to prepare the target solution with many reactants using common dilution operation sharing on digital microfluidic biochips (DMFBs). CoDOS first represents the given target concentration as a recipe matrix, and then identifies rectangles in the matrix, where each rectangle indicates an opportunity of dilution operation sharing for reactant minimization. Experimental results demonstrate that CoDOS can achieve up to 27% of reactant saving as compared with the bit-scanning method in single-target sample preparation. Moreover, even if CoDOS is not developed for multi-target sample preparation, it still outperforms the recent state-of-the-art algorithm, RSMA. Hence, it is convincing that CoDOS is a better alternative for many-reactant sample preparation.

    原文English
    主出版物標題2013 IEEE/ACM International Conference on Computer-Aided Design, ICCAD 2013 - Digest of Technical Papers
    頁面615-621
    頁數7
    DOIs
    出版狀態Published - 2013
    事件2013 32nd IEEE/ACM International Conference on Computer-Aided Design, ICCAD 2013 - San Jose, CA, United States
    持續時間: 18 11月 201321 11月 2013

    出版系列

    名字IEEE/ACM International Conference on Computer-Aided Design, Digest of Technical Papers, ICCAD
    ISSN(列印)1092-3152

    Conference

    Conference2013 32nd IEEE/ACM International Conference on Computer-Aided Design, ICCAD 2013
    國家/地區United States
    城市San Jose, CA
    期間18/11/1321/11/13

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