Safety Evaluation and Anti-Inflammatory Efficacy of Lacticaseibacillus paracasei PS23

Chin Hao Li, Tai Ying Chen, Chien Chen Wu, Shih Hsuan Cheng, Min Yu Chang, Wei Hong Cheng, Shih Hau Chiu, Chien Chi Chen, Ying Chieh Tsai, Deng Jye Yang, Jaw Jou Kang, Po Lin Liao*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Lacticaseibacillus paracasei strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of PS23 revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. In addition, PS23 was sensitive to the tested antibiotics. Genotoxicity tests for PS23 including the Ames test and chromosomal aberrations in vitro using Chinese hamster ovary cells and micronuclei in immature erythrocytes of ICR mice were all negative. Moreover, following a 28-day study involving repeated oral dose toxicity tests (40, 400, and 4000 mg/kg equal 1.28 × 1010, 1.28 × 1011, and 1.28 × 1012 CFU/kg body weight, respectively) using an ICR mouse model, no adverse effects were observed from any doses. In addition, supplementation with live or heat-killed PS23 ameliorates DSS-induced colonic inflammation in mice. Our findings suggest that PS23 is safe and has anti-inflammatory effects and may therefore have therapeutic implications.

原文English
文章編號724
期刊International Journal Of Molecular Sciences
24
發行號1
DOIs
出版狀態Published - 1月 2023

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