S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo

Pekka Rauhala*, K. Parameswarannay Mohanakumar, Istvan Sziraki, Anya M.Y. Lin, Chuang C. Chiueh

*此作品的通信作者

研究成果: Article同行評審

86 引文 斯高帕斯(Scopus)

摘要

Intranigral infusion of ferrous citrate (4.2 nmol) induced an acute lipid peroxidation in the substantia nigra and a chronic dopamine depletion in the striatum of rat nigrostriatal system. Coinfusion of 8.4 nmol nitric oxide donors such as S-nitrosoglutathione (GSNO) and S-nitroso-N- acetylpenicillamine (SNAP) or nitric oxide (~2 nmol) protected nigrostriatal neurons against iron-induced lipid peroxidation and associated oxidative injury. However, sodium nitroprusside (SNP, 8.4 nmol) augmented dopamine depletion caused by ferrous citrate because SNP is a ferricyanide complex. The present in vivo results indicate that nitric oxide and S-nitrosothiols are antioxidants which can protect brain dopamine neurons against oxidant stress/damage.

原文English
頁(從 - 到)58-60
頁數3
期刊Synapse
23
發行號1
DOIs
出版狀態Published - 5月 1996

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