RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens

Chuan Sheng Lin, Jim Tong Horng, Chun Hung Yang, Yu Huan Tsai, Lin Hui Su, Chia Fong Wei, Chang Chieh Chen, Shang Chen Hsieh, Chia Chen Lu, Hsin Chih Lai*

*此作品的通信作者

研究成果: Article同行評審

53 引文 斯高帕斯(Scopus)

摘要

Serratia marcescens has long been recognized as an important opportunistic pathogen, but the underlying pathogenesis mechanism is not completely clear. Here, we report a key pathogenesis pathway in S. marcescens comprising the RssAB two-component system and its downstream elements, FlhDC and the dominant virulence factor hemolysin ShlBA. Expression of shlBA is under the positive control of FlhDC, which is repressed by RssAB signaling. At 37°C, functional RssAB inhibits swarming, represses hemolysin production, and promotes S. marcescens biofilm formation. In comparison, when rssBA is deleted, S. marcescens displays aberrant multicellularity favoring motile swarming with unbridled hemolysin production. Cellular and animal infection models further demonstrate that loss of rssBA transforms this opportunistic pathogen into hypervirulent phenotypes, leading to extensive inflammatory responses coupled with destructive and systemic infection. Hemolysin production is essential in this context. Collectively, a major virulence regulatory pathway is identified in S. marcescens.

原文English
頁(從 - 到)4870-4881
頁數12
期刊Infection and Immunity
78
發行號11
DOIs
出版狀態Published - 11月 2010

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