Role of SODD in regulation of tumor necrosis factor responses

Hidetoshi Takada, Nien Jung Chen, Christine Mirtsos, Shinobu Suzuki, Nobutaka Suzuki, Andrew Wakeham, Tak W. Mak, Wen Chen Yeh*


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51 引文 斯高帕斯(Scopus)


Signaling from tumor necrosis factor receptor type 1 (TNFR1) can elicit potent inflammatory and cytotoxic responses that need to be properly regulated. It was suggested that the silencer of death domains (SODD) protein constitutively associates intracellularly with TNFR1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules that are juxtaposed in the absence of ligand stimulation. In this study, we demonstrate that mice lacking SODD produce larger amounts of cytokines in response to in vivo TNF challenge. SODD-deficient macrophages and embryonic fibroblasts also show altered responses to TNF. TNF-induced activation of NF-κB is accelerated in SODD-deficient cells, but TNF-induced c-Jun N-terminal kinase activity is slightly repressed. Interestingly, the apoptotic arm of TNF signaling is not hyperresponsive in the SODD-deficient cells. Together, these results suggest that SODD is critical for the regulation of TNF signaling.

頁(從 - 到)4026-4033
期刊Molecular and Cellular Biology
出版狀態Published - 6月 2003


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