Risk of dementia after anaesthesia and surgery

Pin Liang Chen, Chih Wen Yang, Yi Kuan Tseng, Wei Zen Sun, Jane Ling Wang, Shuu Jiun Wang, Yen Jen Oyang, Jong Ling Fuh*


研究成果: Article同行評審

109 引文 斯高帕斯(Scopus)


Background The potential relationship between anaesthesia, surgery and onset of dementia remains elusive. Aims To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia. Method The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia. Results Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio = 1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia. Conclusions The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.

頁(從 - 到)188-193
期刊British Journal of Psychiatry
出版狀態Published - 3月 2014


深入研究「Risk of dementia after anaesthesia and surgery」主題。共同形成了獨特的指紋。