Risk factors for delayed perineal wound healing and its impact on prolonged hospital stay after abdominoperineal resection

Chu Cheng Chang, Yuan Tzu Lan*, Jeng Kai Jiang, Shih Ching Chang, Shung Haur Yang, Chun Chi Lin, Hung Hsin Lin, Huann Sheng Wang, Wei Shone Chen, Tzu Chen Lin, Jen Kou Lin

*此作品的通信作者

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Background: Perineal wound complications are a long-lasting issue for abdominoperineal resection (APR) patients. Complication rates as high as 60% have been reported, with the most common complication being delayed perineal wound healing. The aim of this study was to identify risk factors for delayed perineal wound healing and its impact on prolonged hospital stay. Methods: We included low rectal tumor patients who underwent APR at a referral medical center from April 2002 to December 2017; a total of 229 patients were included. The basic characteristics and surgical outcomes of the patients were analyzed to identify risk factors for delayed perineal wound healing (> 30 days after APR) and prolonged hospital stay (post-APR hospital stay > 14 days). Results: All patients received primary closure for their perineal wound. The majority of patients were diagnosed with adenocarcinoma (N = 213, 93.1%). In the univariate analysis, patients with hypoalbuminemia (albumin < 3.5 g/dL) had an increased risk of delayed wound healing (39.5% vs. 60.5%, P = 0.001), which was an independent risk factor in the multivariable analysis (OR 2.962, 95% CI 1.437-6.102, P = 0.003). Patients with delayed wound healing also had a significantly increased risk of prolonged hospital stay (OR 6.404, 95% CI 3.508-11.694, P < 0.001). Conclusions: Hypoalbuminemia was an independent risk factor for delayed wound healing, which consequently led to a prolonged hospital stay. Further clinical trials are needed to reduce the incidence of delayed perineal wound healing by correcting albumin levels or nutritional status before APR.

原文English
文章編號226
期刊World Journal of Surgical Oncology
17
發行號1
DOIs
出版狀態Published - 21 12月 2019

指紋

深入研究「Risk factors for delayed perineal wound healing and its impact on prolonged hospital stay after abdominoperineal resection」主題。共同形成了獨特的指紋。

引用此