Risk factors for anisometropia in schoolchildren: A population-based, longitudinal cohort study

Chia Wei Lee, Chi Chen Chiang, Der Chong Tsai, Ching Yao Tsai, Yiing Mei Liou*


研究成果: Article同行評審


Purpose: To investigate the incidence rate and risk factors for anisometropia among young schoolchildren. Methods: A population-based cohort study, the Myopia Investigation Study in Taipei, was conducted in primary schools in Taipei City. Children were recruited for biannual comprehensive eye examinations over 2 years. Cycloplegic autorefraction and slit lamp examinations were performed biannually. Data on demographic information, parental history, lifestyle and near-work activities were collected using parent-administered questionnaires at the first and final visits. Anisometropia was defined as ≥1 D difference in the spherical equivalent (SE) refractive error. Results: A total of 7035 8-year-old children completed the 2-year follow-up evaluations. The average annual incidence of anisometropia was 3.8%. Multivariable logistic regression analysis revealed that baseline SE (odds ratio [OR]: 0.87 95% CI: 0.80–0.95) and female sex (OR: 1.24, 95% confidence interval [CI]: 1.02–1.50) were significantly associated with incident anisometropia. Among lifestyle risk factors, spending <1 h per day in after-school outdoor activities on weekdays (OR: 1.38, 95% CI: 1.08–1.76) and performing near work at a distance <30 cm (OR: 1.33, 95% CI: 1.08–1.64) were significantly associated with an increased risk of incident anisometropia. In the multiple linear regression analysis, the inter-eye difference in SE increased significantly in children performing near work at distances <30 cm (adjusted β = 0.03; p = 0.02). Conclusions: This study indicated the annual incidence of anisometropia in Taiwanese schoolchildren. Less time spent outdoors and shorter eye-to-object distances during near work increased the risk of incident anisometropia.

頁(從 - 到)1500-1509
期刊Ophthalmic and Physiological Optics
出版狀態Published - 11月 2023


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