Ribavirin enhances interferon-γ levels in patients with chronic hepatitis C treated with interferon-α

Shih Hua Fang, Ming Yang Lai, Lin Hwa Hwang, Pei Ming Yang, Pei Jer Chen, Bor Luen Chiang*, Ding Shinn Chen


研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)


Some patients with chronic hepatitis C respond to interferon (IFN)-α treatment, and the efficiency can be improved by combining it with ribavirin. The mechanism of this improvement is unknown. To investigate the effects of these two regimens on the immune responses in 51 patients with chronic hepatitis C, we examined the hepatitis C core antigen-specific proliferative response and cytokine production profiles, natural killer (NK) cell cytotoxicity and cytotoxic T cell function during treatment. The results are as follows: (1) both viral clearance and biochemical normalization occurred more frequently in patients receiving combination therapy; (2) the function of NK cells increased after treatment in the responders of both groups (p < 0.05); (3) the level of IFN-γ produced by hepatitis C core antigen-stimulated peripheral blood mononuclear cells was higher in patients receiving combination therapy, especially in responders; (4) the core antigen-specific proliferative response decreased after treatment, and (5) in addition, the core-specific cytotoxic T cell activities of five responder patients also increased significantly after therapy. In conclusion, enhancement of immune responses, especially those related to type-1 T helper cell activity, may contribute to better efficacy in combining ribavirin with IFN-α for treatment of chronic hepatitis C.

頁(從 - 到)484-491
期刊Journal of Biomedical Science
出版狀態Published - 2001


深入研究「Ribavirin enhances interferon-γ levels in patients with chronic hepatitis C treated with interferon-α」主題。共同形成了獨特的指紋。