Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

Yun-Ming Wang; Yueh Ju Wang; Reu Sheng Sheu; Gin Chung Liu; Wen Chen Lin; Ju Hsiou Liao

doi:10.1016/S0277-5387(98)00406-9

Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

Yun-Ming Wang^*, Yueh Ju Wang, Reu Sheng Sheu, Gin Chung Liu, Wen Chen Lin, Ju Hsiou Liao

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分子醫學與生物工程研究所

研究成果: Article › 同行評審

31 引文斯高帕斯（Scopus）

摘要

A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H₅dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H₃L), has been synthesized. The crystal structure of gadolinium(III) complex of H₃L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. ¹⁷O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.

原文	English
頁（從 - 到）	1147-1152
頁數	6
期刊	Polyhedron
卷	18
發行號	8-9
DOIs	https://doi.org/10.1016/S0277-5387(98)00406-9
出版狀態	Published - 12 3月 1999

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title = "Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging",

abstract = "A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H5dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. 17O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.",

keywords = "Contrast agent, MRI, Paramagnetic gadolinium(III) complex, Relaxivity",

author = "Yun-Ming Wang and Wang, {Yueh Ju} and Sheu, {Reu Sheng} and Liu, {Gin Chung} and Lin, {Wen Chen} and Liao, {Ju Hsiou}",

year = "1999",

month = mar,

day = "12",

doi = "10.1016/S0277-5387(98)00406-9",

language = "English",

volume = "18",

pages = "1147--1152",

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number = "8-9",

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TY - JOUR

T1 - Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

AU - Wang, Yun-Ming

AU - Wang, Yueh Ju

AU - Sheu, Reu Sheng

AU - Liu, Gin Chung

AU - Lin, Wen Chen

AU - Liao, Ju Hsiou

PY - 1999/3/12

Y1 - 1999/3/12

N2 - A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H5dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. 17O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.

AB - A new bis(amide) derivative of diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid (H5dtpa), diethylenetriamine-N,N′,N″-triacetic-N,N″-bis(2- methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. 17O NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement.

KW - Contrast agent

KW - MRI

KW - Paramagnetic gadolinium(III) complex

KW - Relaxivity

UR - http://www.scopus.com/inward/record.url?scp=0041192901&partnerID=8YFLogxK

U2 - 10.1016/S0277-5387(98)00406-9

DO - 10.1016/S0277-5387(98)00406-9

M3 - Article

AN - SCOPUS:0041192901

SN - 0277-5387

VL - 18

SP - 1147

EP - 1152

JO - Polyhedron

JF - Polyhedron

IS - 8-9

ER -

Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N″-triacetic acid-N,N″-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

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