Regulation of clc-2 chloride channel proteostasis by molecular chaperones: Correction of leukodystrophy-associated defect

Keyphrases

• 17-allylamino-17-demethoxygeldanamycin 37%
• ATP Synthase 12%
• Biochemical Analysis 12%
• Chaperone 12%
• Chaperone System 12%
• Chloride Channel 100%
• ClC-2 100%
• ClC-2 Chloride Channel 25%
• CLCN2 12%
• Co-chaperone 25%
• Endoplasmic Reticulum Quality Control 12%
• Endoplasmic Reticulum-associated Degradation 12%
• FK506-binding Protein 25%
• Gain-of-function mutation 12%
• Gene-deficient Mice 12%
• Heat Shock Protein 90 (Hsp90) 62%
• Heat Shock Proteins 12%
• Hsc70 25%
• Hsp70 Chaperone 12%
• HSP70 Heat-shock Proteins 12%
• Ion Homeostasis 12%
• Leukodystrophy 100%
• Leydig Cells 12%
• Loss Function 12%
• Membrane Trafficking 12%
• Molecular Chaperone 100%
• Myelin Vacuolation 12%
• Protein Biogenesis 12%
• Protein Complex 12%
• Protein Level 12%
• Proteostasis 100%
• Quality Control System 12%
• Small Molecules 12%
• Surface Proteins 12%
• Testicle 12%
• Testicular Degeneration 12%
• Testicular Tissue 12%
• Therapeutic Potential 12%
• Tissue Cells 12%
• White Matter Disease 12%

Biochemistry, Genetics and Molecular Biology

• ATPase 20%
• Binding Protein 40%
• Biogenesis 20%
• Cell Surface Protein 20%
• Chaperone Protein 100%
• Chloride Channel 100%
• CLCN2 20%
• Co-Chaperone 40%
• Endoplasmic-Reticulum-Associated Protein Degradation 20%
• Heat Shock 20%
• Heat Shock Protein 100%
• Homeostasis 20%
• Hsp70 20%
• Loss of Function Mutation 20%
• Membrane Trafficking 20%
• Myelin 20%
• Protein Complexes 20%
• Protein Homeostasis 100%
• Quality Control 20%
• Small Molecule 20%