Regenerative hair waves in aging mice and extra-follicular modulators follistatin, Dkk1, and Sfrp4

Chih Chiang Chen, Philip J. Murray, Ting Xin Jiang, Maksim V. Plikus, Yun Ting Chang, Oscar K. Lee, Randall B. Widelitz, Cheng Ming Chuong*

*此作品的通信作者

研究成果: Article同行評審

57 引文 斯高帕斯(Scopus)

摘要

Hair cycling is modulated by factors both intrinsic and extrinsic to hair follicles. Cycling defects lead to conditions such as aging-associated alopecia. Recently, we demonstrated that mouse skin exhibits regenerative hair waves, reflecting a coordinated regenerative behavior in follicle populations. Here, we use this model to explore the regenerative behavior of aging mouse skin. Old mice (>18 months) tracked over several months show that with progressing age, hair waves slow down, wave propagation becomes restricted, and hair cycle domains fragment into smaller domains. Transplanting aged donor mouse skin to a young host can restore donor cycling within a 3 mm range of the interface, suggesting that changes are due to extracellular factors. Therefore, hair stem cells in aged skin can be reactivated. Molecular studies show that extra-follicular modulators Bmp2, Dkk1, and Sfrp4 increase in early anagen. Further, we identify follistatin as an extra-follicular modulator, which is highly expressed in late telogen and early anagen. Indeed, follistatin induces hair wave propagation and its level decreases in aging mice. We present an excitable medium model to simulate the cycling behavior in aging mice and illustrate how the interorgan macroenvironment can regulate the aging process by integrating both "activator" and "inhibitor" signals.

原文English
頁(從 - 到)2086-2096
頁數11
期刊Journal of Investigative Dermatology
134
發行號8
DOIs
出版狀態Published - 8月 2014

指紋

深入研究「Regenerative hair waves in aging mice and extra-follicular modulators follistatin, Dkk1, and Sfrp4」主題。共同形成了獨特的指紋。

引用此