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Real-time bioluminescent assay for inhibitors of RNA and DNA polymerases and other ATP-dependent enzymes
Kalvin J. Gregory
*
, Ye Sun,
G. Chen
, Valeri Golovlev
*
此作品的通信作者
電機工程學系
研究成果
:
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同行評審
3
引文 斯高帕斯(Scopus)
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Keyphrases
RNA-dependent RNA Polymerase (RdRP)
100%
Polymerase
100%
Bioluminescent Assay
100%
DNA Polymerase
100%
ATP-dependent Enzymes
100%
Change of Measure
50%
Drug Development
50%
Kinetic Study
50%
Inhibition Mechanism
50%
Inhibition Constant
50%
Inhibitor Concentration
50%
Viral Polymerase
50%
Substrate Concentration
50%
RNA Template
50%
Michaelis-Menten
50%
Non-competitive Inhibitor
50%
Competitive Inhibitor
50%
Klenow Fragment
50%
Km Value
50%
HIV-1 Reverse Transcriptase
50%
Enzyme Inhibition
50%
Number of Experiments
50%
DNA Template
50%
Fragment-based Drug Discovery
50%
Pharmacology, Toxicology and Pharmaceutical Science
Adenosine Triphosphate
100%
RNA Polymerase
100%
DNA Polymerase
100%
Drug Development
25%
Drug Discovery
25%
RNA Directed DNA Polymerase
25%
Competitive Inhibitor
25%
Enzyme Inhibition
25%