Rat mesenchymal cell CD44 surface markers: Role in cardiomyogenic differentiation

Tze Wen Chung*, Ming Chia Yang

*此作品的通信作者

研究成果: Chapter同行評審

摘要

We reported that hyaluronic acid (HA) containing silk fibroin (SF) patches markedly improved cardiomyogenic differentiation of 5-aza inducing rat mesenchymal stem cells (rMSCs). It is well known that MSCs contain an abundant of CD44 surface markers, and HA is the receptor of those markers. Examining the roles of CD44 markers on cardiomyogenic differentiation of rMSCs might help to design new cardiac patches for cell therapy in infarcted hearts. To study the issue, 5-aza inducing rMSCs with or without a CD44-blockage treatment was cultured in SF/HA cardiac patches; the expressions of cardiac genes and specific cardiac proteins as an index of cardiomyogenic differentiation were examined in the end of the cultivation. It was found that the expressions of cardiac genes such as Gata4 and Nkx2.5 and proteins such as cardiotin and connexion 43, and were significantly decreased for the rMSCs with a CD44-blockage treatment.We conclude that the surface markers of CD44 of rMSCs highly modulate the cardiomyogenic differentiation of the cells when they are cultivated on SF/HA cardiac patches.

原文English
主出版物標題Stem Cells and Cancer Stem Cells, Volume 2
主出版物子標題Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2
發行者Springer Netherlands
頁面185-190
頁數6
ISBN(電子)9789400720169
ISBN(列印)9789400720152
DOIs
出版狀態Published - 1 1月 2012

指紋

深入研究「Rat mesenchymal cell CD44 surface markers: Role in cardiomyogenic differentiation」主題。共同形成了獨特的指紋。

引用此