@inproceedings{2c57607cf8fe4674b7b47f3001e8ec42,
title = "Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O2 in single red blood cell",
abstract = "Raman spectroscopy has been shown to have the potential for providing oxygenated ability of erythrocytes. Raman line at 1638 cm-1 has also been reported as one significant oxygenic indicator for erythrocytes. In this research, we develop the Raman spectroscopic monitoring of the bioeffects of Nitroglycerin on hemoglobin oxygen saturation in a single red blood cell (RBC). Nitroglycerin has been frequently used in the management of angina pectoris. Nitroglycerin liberates nitric oxide (NO) to blood vessels. NO is an oxidizer that easily converts hemoglobin to methemoglobin. The conversion may cause the decrease of oxygenated ability of erythrocytes. In this study, we observed the oxidize state of erythrocytes caused by the over dosage of Nitroglycerin. When the dose of Nitroglycerin exceeds 2×10-4 M, the oxygenic state of erythrocytes decreases significantly. The Raman spectroscopic results demonstrate the observation of the bioeffects of Nitroglycerin on hemoglobin.",
keywords = "Erythrocyte, Nitroglycerin, Oxygen, Raman spectroscopy",
author = "Chiang, {Huihua Kenny} and Ruan, {Hung Shiang} and Cheng, {Hung You} and Fang, {Tung Ting}",
year = "2007",
doi = "10.1117/12.700380",
language = "English",
isbn = "0819465437",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Advanced Biomedical and Clinical Diagnostic Systems V",
note = "Advanced Biomedical and Clinical Diagnostic Systems V ; Conference date: 21-01-2007 Through 27-01-2007",
}