Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O2 in single red blood cell

Huihua Kenny Chiang*, Hung Shiang Ruan, Hung You Cheng, Tung Ting Fang

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Raman spectroscopy has been shown to have the potential for providing oxygenated ability of erythrocytes. Raman line at 1638 cm-1 has also been reported as one significant oxygenic indicator for erythrocytes. In this research, we develop the Raman spectroscopic monitoring of the bioeffects of Nitroglycerin on hemoglobin oxygen saturation in a single red blood cell (RBC). Nitroglycerin has been frequently used in the management of angina pectoris. Nitroglycerin liberates nitric oxide (NO) to blood vessels. NO is an oxidizer that easily converts hemoglobin to methemoglobin. The conversion may cause the decrease of oxygenated ability of erythrocytes. In this study, we observed the oxidize state of erythrocytes caused by the over dosage of Nitroglycerin. When the dose of Nitroglycerin exceeds 2×10-4 M, the oxygenic state of erythrocytes decreases significantly. The Raman spectroscopic results demonstrate the observation of the bioeffects of Nitroglycerin on hemoglobin.

原文English
主出版物標題Advanced Biomedical and Clinical Diagnostic Systems V
DOIs
出版狀態Published - 2007
事件Advanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, 美國
持續時間: 21 1月 200727 1月 2007

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
6430
ISSN(列印)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic Systems V
國家/地區美國
城市San Jose, CA
期間21/01/0727/01/07

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