Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

Jia Pu Syu, Min Jyun Su, Po Wei Chen, Chang Chih Ke, Shih Hwa Chiou*, Wen Chuan Kuo

*此作品的通信作者

研究成果: Conference contribution同行評審

1 引文 斯高帕斯(Scopus)

摘要

This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS rats (55 weeks), the thickness of photoreceptor layer decreased significantly as compared to young RCS rats (both 4 weeks and 5 weeks). After contrast enhancement method, this platform will be useful for the quantitative evaluation of the degree of retinal degeneration, treatment outcome after therapy, and drug screening development in the future.

原文English
主出版物標題Ophthalmic Technologies XXVIII
編輯Arthur Ho, Per G. Soderberg, Fabrice Manns
發行者SPIE
ISBN(電子)9781510614338
DOIs
出版狀態Published - 2018
事件28th Conference on Ophthalmic Technologies - San Francisco, United States
持續時間: 27 1月 201828 1月 2018

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10474
ISSN(列印)1605-7422

Conference

Conference28th Conference on Ophthalmic Technologies
國家/地區United States
城市San Francisco
期間27/01/1828/01/18

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