Quantification of structural and microvascular changes for diagnosing early-stage oral cancer

Ping Hsien Chen, Yu Ju Chen, Yi Fen Chen, Yi Chen Yeh, Kuo Wei Chang, Ming Chih Hou, Wen Chuan Kuo*

*此作品的通信作者

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.

原文English
頁(從 - 到)1244-1256
頁數13
期刊Biomedical Optics Express
11
發行號3
DOIs
出版狀態Published - 1 3月 2020

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