Pyridoxal 5′-phosphate binding in lysine-modified PAMAM dendrimers: A biomimetic approach

Kuang Chan Hsien; Hui Ting Chen; Yi Chen Chen; Yeh Long Chen; Chi Yu Lu; Chai Lin Kao

doi:10.1021/ol901299e

Pyridoxal 5′-phosphate binding in lysine-modified PAMAM dendrimers: A biomimetic approach

Kuang Chan Hsien^*, Hui Ting Chen, Yi Chen Chen, Yeh Long Chen, Chi Yu Lu, Chai Lin Kao

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摘要

Image Persented (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)_x (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5′-phosphate. The results revealed a positive dendritic effect, and binding ability was found to vary with the environment. (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)_x (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding. The strongest binding affinity was K_b = 254.3 mM ^-1 at pH 9, which was shown by (G:7)-dendri-PAMAM-(APO-Phe-Lys) ₄₉₀ (2e).

原文	English
頁（從 - 到）	3526-3529
頁數	4
期刊	Organic Letters
卷	11
發行號	16
DOIs	https://doi.org/10.1021/ol901299e
出版狀態	Published - 20 8月 2009

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10.1021/ol901299e

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title = "Pyridoxal 5′-phosphate binding in lysine-modified PAMAM dendrimers: A biomimetic approach",

abstract = "Image Persented (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5′-phosphate. The results revealed a positive dendritic effect, and binding ability was found to vary with the environment. (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding. The strongest binding affinity was Kb = 254.3 mM -1 at pH 9, which was shown by (G:7)-dendri-PAMAM-(APO-Phe-Lys) 490 (2e).",

author = "Hsien, {Kuang Chan} and Chen, {Hui Ting} and Chen, {Yi Chen} and Chen, {Yeh Long} and Lu, {Chi Yu} and Kao, {Chai Lin}",

year = "2009",

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doi = "10.1021/ol901299e",

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T1 - Pyridoxal 5′-phosphate binding in lysine-modified PAMAM dendrimers

T2 - A biomimetic approach

AU - Hsien, Kuang Chan

AU - Chen, Hui Ting

AU - Chen, Yi Chen

AU - Chen, Yeh Long

AU - Lu, Chi Yu

AU - Kao, Chai Lin

PY - 2009/8/20

Y1 - 2009/8/20

N2 - Image Persented (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5′-phosphate. The results revealed a positive dendritic effect, and binding ability was found to vary with the environment. (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding. The strongest binding affinity was Kb = 254.3 mM -1 at pH 9, which was shown by (G:7)-dendri-PAMAM-(APO-Phe-Lys) 490 (2e).

AB - Image Persented (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5′-phosphate. The results revealed a positive dendritic effect, and binding ability was found to vary with the environment. (G:3-7)-dendri-PAMAM-(APO-Phe-Lys)x (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding. The strongest binding affinity was Kb = 254.3 mM -1 at pH 9, which was shown by (G:7)-dendri-PAMAM-(APO-Phe-Lys) 490 (2e).

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JO - Organic Letters

JF - Organic Letters

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ER -

Pyridoxal 5′-phosphate binding in lysine-modified PAMAM dendrimers: A biomimetic approach

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