Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei Lun Chiang, Cherng Jyh Ke, Zi Xian Liao, San-Yuan Chen, Fu Rong Chen, Chun Ying Tsai, Younan Xia*, Hsing Wen Sung

*此作品的通信作者

研究成果: Article同行評審

78 引文 斯高帕斯(Scopus)

摘要

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.

原文English
頁(從 - 到)3584-3588
頁數5
期刊Small
8
發行號23
DOIs
出版狀態Published - 7 12月 2012

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