Proteomic changes associated with metabolic syndrome in a fructose-fed rat model

Cheng Chu Hsieh, Chen Chung Liao, Yi Chun Liao, Lucy Sun Hwang, Liang Yi Wu, Shu Chen Hsieh*


研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)


Metabolic syndrome (MetS), characterized by a constellation of disorders such as hyperglycemia, insulin resistance, and hypertension, is becoming a major global public health problem. Fructose consumption has increased dramatically over the past several decades and with it the incidence of MetS. However, its molecular mechanisms remain to be explored. In this study, we used male Sprague-Dawley (SD) rats to study the pathological mechanism of fructose induced MetS. The SD rats were fed a 60% high-fructose diet for 16 weeks to induce MetS. The induction of MetS was confirmed by blood biochemistry examination. Proteomics were used to investigate the differential hepatic protein expression patterns between the normal group and the MetS group. Proteomic results revealed that fructose-induced MetS induced changes in glucose and fatty acid metabolic pathways. In addition, oxidative stress and endoplasmic reticulum stress-related proteins were modulated by high-fructose feeding. In summary, our results identify many new targets for future investigation. Further characterization of these proteins and their involvement in the link between insulin resistance and metabolic dyslipidemia may bring new insights into MetS.

頁(從 - 到)754-761
期刊Journal of Food and Drug Analysis
出版狀態Published - 1 10月 2016


深入研究「Proteomic changes associated with metabolic syndrome in a fructose-fed rat model」主題。共同形成了獨特的指紋。