Protein-mediated DNA looping in a fluctuating micromechanical environment

J. N. Milstein, Yih Fan Chen, Jens Christian Meiners

研究成果: Conference contribution同行評審

2 引文 斯高帕斯(Scopus)


Forces on the order of a hundred femtonewtons can drastically prevent the formation of protein-mediated DNA loops, which are a common regulatory component of cellular function and control. To investigate how such an acutely sensitive mechanism might operate within a noisy environment, as might typically be experienced within a cell, we have studied the response of DNA loop formation under an optically induced, fluctuating, mechanical tension. We show that mechanical noise strongly enhances the rate of loop formation. Moreover, the sensitivity of the loop formation rate to mechanical fluctuations is relatively independent of the baseline tension. This suggests that tension along the DNA molecule could act as a robust means of regulating transcription in a noisy in vivo environment.

主出版物標題Optical Trapping and Optical Micromanipulation VII
出版狀態Published - 2010
事件Optical Trapping and Optical Micromanipulation VII - San Diego, CA, United States
持續時間: 1 8月 20105 8月 2010


名字Proceedings of SPIE - The International Society for Optical Engineering


ConferenceOptical Trapping and Optical Micromanipulation VII
國家/地區United States
城市San Diego, CA


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