PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility

Yao Yuan Hsieh, Ian Pan Chan, Hsin I. Wang, Chi Chen Chang, Ching Wei Huang, Chih-Sheng Lin*


研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


Objective: Leiomyoma and hyperprolactinaemia are both progesterone- dependent diseases. Hormone-related genes, such as the progesterone receptor (PGR), might be involved in their pathogenesis. Design and measurements: Subjects were divided into three groups: (i) leiomyoma (n = 120); (ii) hyperprolactinaemia (n = 101); (iii) normal controls (n = 140). We investigated the Alu (306-bp DNA) insertion in intron G of the PGR gene in all individuals. PGR gene polymorphisms [T1 (wild-type); T2 (PROGINS, with Alu insertion)] were determined by PCR and electrophoresis. Genotype and allele frequencies of the PROGINS in each group were detected and compared. Results: We observed no significant difference of the PGRT1/T2 genotypes and allele frequencies between leiomyoma and other two groups. The proportions of T1 homozygote/heterozygote/T2 homozygote in each group were (i) 90/8.3/1.7%; (ii) 84.2/9.9/5.9%; (iii) 92.9/6.4/0.7%. In contrast, a higher percentage of T2-related genotype and allele were noted in hyperprolactinaemic women compared to other two groups. The proportions of T1/T2 alleles in each group were: (i) 94.2/5.8%; (ii) 89.1/10.9%; (iii) 96.1/3.9%. Conclusions: The PROGIN*T2-related genotype and allele are related to a higher susceptibility to hyperprolactinaemia. The PROGINS polymorphism is not associated with leiomyoma development.

頁(從 - 到)492-497
期刊Clinical Endocrinology
出版狀態Published - 1 4月 2005


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