Profiles of oral microbiome associated with nasogastric tube feeding

Ding Han Wang, Fa Tzu Tsai, Hsi Feng Tu, Cheng Chieh Yang, Ming Lun Hsu, Lin Jack Huang, Chiu Tzu Lin, Wun Eng Hsu, Yu Cheng Lin*

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Dysbiosis of oral microbiome causes chronic diseases including dental caries and periodontitis, which frequently affect older patient populations. Severely disabled individuals with impaired swallowing functions may require nutritional supply via nasogastric (NG) tubes, further impacting their oral condition and possibly microbial composition. However, little is known about the effect of NG tube on oral microbes and its potential ramification. Methods: By using 16S rRNA amplicon sequencing, we characterized the tongue microbiome of 27 patients fed with NG tubes and 26 others fed orally. Results: The microbial compositions of NG-tube and oral-feeding patients were substantially different, with more Gram-negative aerobes enriched in the presence of NG tube. Specifically, NG-tube patients presented more opportunistic pathogens like Pseudomonas and Corynebacterium associated with pneumonia and lower levels of commensal Streptococcus and Veillonella. Co-occurrence analysis further showed an inverse relationship between commensal and pathogenic species. Conclusion: We present a systematic, high-throughput profiling of oral microbiome with regard to long-term NG tube feeding among the older patient population.

原文English
文章編號2200898
期刊Journal of Oral Microbiology
15
發行號1
DOIs
出版狀態Published - 2023

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