@inproceedings{fb12553941b44242b6501db90b1e53bc,
title = "Probing the interior of synaptic vesicles with internalized nanoparticles",
abstract = "Synaptic vesicles are subcellular organelles that are found in the synaptic bouton and are responsible for the propagation of signals between neurons. Synaptic vesicles undergo endo- and exocytosis with the neuronal membrane to load and release neurotransmitters. Here we discuss how we utilize this property to load nanoparticles as a means of probing the interior of synaptic vesicles. To probe the intravesicular region of synaptic vesicles, we have developed a highly sensitive pH-sensing polymer dot. We feel the robust nature of the pH-sensing polymer dot will provide insight into the dynamics of proton loading into synaptic vesicles.",
keywords = "F{\"o}rster resonance energy transfer (FRET), PH sensor, Polymer dots, Single molecule, Synaptic vesicles, Synaptosome",
author = "Gadd, {Jennifer C.} and Budzinski, {Kristi L.} and Yang-Hsiang Chan and Fangmao Ye and Chiu, {Daniel T.}",
year = "2012",
month = apr,
day = "2",
doi = "10.1117/12.905091",
language = "English",
isbn = "9780819488756",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Colloidal Nanocrystals for Biomedical Applications VII",
note = "Colloidal Nanocrystals for Biomedical Applications VII ; Conference date: 21-01-2012 Through 22-01-2012",
}