Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Ging Ho Hsiue; Chun Liang Lo; Ching Hao Cheng; Che Ping Lin; Chun Kai Huang; Hung Hao Chen

doi:10.1002/pola.21741

Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Ging Ho Hsiue^*, Chun Liang Lo, Ching Hao Cheng, Che Ping Lin, Chun Kai Huang, Hung Hao Chen

^*此作品的通信作者

生物醫學工程學系

研究成果: Article › 同行評審

48 引文斯高帕斯（Scopus）

摘要

A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by ¹H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

原文	English
頁（從 - 到）	688-698
頁數	11
期刊	Journal of Polymer Science, Part A: Polymer Chemistry
卷	45
發行號	4
DOIs	https://doi.org/10.1002/pola.21741
出版狀態	Published - 15 2月 2007

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title = "Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles",

abstract = "A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).",

keywords = "Atom transfer radical polymerization (ATRP), Diblock copolymers, Nanoparticles, Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), Poly(D,L-lactide) (PLA)",

author = "Hsiue, {Ging Ho} and Lo, {Chun Liang} and Cheng, {Ching Hao} and Lin, {Che Ping} and Huang, {Chun Kai} and Chen, {Hung Hao}",

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T1 - Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

AU - Hsiue, Ging Ho

AU - Lo, Chun Liang

AU - Cheng, Ching Hao

AU - Lin, Che Ping

AU - Huang, Chun Kai

AU - Chen, Hung Hao

PY - 2007/2/15

Y1 - 2007/2/15

N2 - A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

AB - A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

KW - Atom transfer radical polymerization (ATRP)

KW - Diblock copolymers

KW - Nanoparticles

KW - Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)

KW - Poly(D,L-lactide) (PLA)

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U2 - 10.1002/pola.21741

DO - 10.1002/pola.21741

M3 - Article

AN - SCOPUS:33847417136

SN - 0887-624X

VL - 45

SP - 688

EP - 698

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 4

ER -

Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

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