TY - JOUR
T1 - Precision medicine for frontotemporal dementia
AU - Liu, Mu N.
AU - Lau, Chi Ieong
AU - Lin, Ching Po
N1 - Publisher Copyright:
Copyright © 2019 Liu, Lau and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
PY - 2019
Y1 - 2019
N2 - Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function. The disease may exhibit similar characteristics to many psychiatric disorders owing to its prominent behavioral features. The concept of precision medicine has recently emerged, and it involves neurodegenerative disease treatment that is personalized to match an individual's specific pattern of neuroimaging, neuropathology, and genetic variability. In this paper, the pathophysiology underlying FTD, which is characterized by the selective degeneration of the frontal and temporal cortices, is reviewed. We also discuss recent advancements in FTD research from the perspectives of clinical, imaging, molecular characterizations, and treatment. This review focuses on the approach of precision medicine to manage the clinical and biological complexities of FTD.
AB - Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function. The disease may exhibit similar characteristics to many psychiatric disorders owing to its prominent behavioral features. The concept of precision medicine has recently emerged, and it involves neurodegenerative disease treatment that is personalized to match an individual's specific pattern of neuroimaging, neuropathology, and genetic variability. In this paper, the pathophysiology underlying FTD, which is characterized by the selective degeneration of the frontal and temporal cortices, is reviewed. We also discuss recent advancements in FTD research from the perspectives of clinical, imaging, molecular characterizations, and treatment. This review focuses on the approach of precision medicine to manage the clinical and biological complexities of FTD.
KW - Frontotemporal dementia
KW - Frontotemporal lobar degeneration
KW - Genetics
KW - Neuroimaging
KW - Precision medicine
KW - Primary progressive aphasia
UR - http://www.scopus.com/inward/record.url?scp=85065911308&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2019.00075
DO - 10.3389/fpsyt.2019.00075
M3 - Review article
AN - SCOPUS:85065911308
SN - 1664-0640
VL - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - FEB
M1 - 75
ER -
