Post-traumatic stress disorder and risk of osteoporosis: A nationwide longitudinal study

Wei Sheng Huang, Ju Wei Hsu, Kai Lin Huang, Ya Mei Bai, Tung Ping Su, Cheng Ta Li, Wei Chen Lin, Tzeng-Ji Chen, Shih Jen Tsai, Ying Jay Liou*, Mu Hong Chen


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16 引文 斯高帕斯(Scopus)


Several studies suggested a relationship between stress and related mental illnesses, such as depression and osteoporosis. However, it was unclear whether patients with post-traumatic stress disorder (PTSD) were at risk of developing osteoporosis in later life. In this study, 6,041 patients with PTSD and 24,164 age- or sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Cases of osteoporosis were identified during the follow-up. Patients with PTSD had an elevated likelihood of developing osteoporosis (HR: 2.66, 95% CI [1.91, 3.71]) in later life compared with the controls. Sensitivity tests after excluding the first year observation (HR: 2.46, 95% CI [1.72, 3.53]) and the first 3-year observation (HR: 1.88, 95% CI [1.18, 3.01]) were consistent. Patients with PTSD had a higher risk of developing osteoporosis at an earlier age compared with those without PTSD. Further studies would be necessary to clarify the pathophysiology between PTSD and osteoporosis.

頁(從 - 到)440-445
期刊Stress and Health
出版狀態Published - 8月 2018


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