Polyphenol-rich longan (Dimocarpus longan Lour.)-flower-water-extract attenuates nonalcoholic fatty liver via decreasing lipid peroxidation and downregulating matrix metalloproteinases-2 and -9

Cheng Wei Liu, Deng Jye Yang, Yuan Yen Chang, Chin Lin Hsu, Jung Kai Tseng, Ming Hsu Chang, Meiling Wang, Yi Chen Chen*

*此作品的通信作者

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Longan-flower-water-extract (LFWE) contains large amounts of phytochemicals where gentisic acid and epicatechin are the major compounds in phenolic acid and flavonoid compound, respectively. The objective of this study was to investigate if drinking LFWE could protect the liver from a hypercaloric dietary habit. Only rats fed the hypercaloric diet (HCD) with 25. g/L (w/v) LFWE solution (HCD_2X) group demonstrated lower (p<0.05) serum triglyceride levels compared to those fed the HCD with normal distilled water (HCD_NDW) and HCD with 12.5. g/L (w/v) LFWE solution (HCD_1X) groups. However, drinking LFWEs decreased (p<0.05) hepatic lipids in the HCD rats. Lower (p<0.05) hepatic MDA levels, GOT and GPT values, and higher (p<0.05) hepatic GSH levels were observed in HCD rats drinking LFWE. Besides, drinking LFWE downregulated (p<0.05) gene expressions and activities of hepatic matrix metalloproteinases-2 and -9 (MMP-2/9) in HCD rats. In conclusion, polyphenol-rich LFWE displayed hepatoprotective characteristics against an energy-dense dietary habit.

原文English
頁(從 - 到)444-449
頁數6
期刊Food Research International
45
發行號1
DOIs
出版狀態Published - 1月 2012

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