Polymer-liposome complexes with a functional hydrogen-bond cross-linker for preventing protein adsorption and improving tumor accumulation

Yi Ting Chiang, Yung Ting Cheng, Chih Yang Lu, Yu Wei Yen, Lu Yi Yu, Kun Siou Yu, Sih Ying Lyu, Chieh Yu Yang, Chun Liang Lo*

*此作品的通信作者

研究成果: Article同行評審

38 引文 斯高帕斯(Scopus)

摘要

To solve biostability and organ distribution problems in polymer-coated liposomes, this study developed tumor-extracellular matrix pH-induced targeting polymer-liposome complexes (ECM-targeting liposomes) that are highly stable in a protein-rich environment and can trigger targeting ability in tumor ECM environment. Experimental results show that the ECM-targeting liposomes significantly reduced adsorption of various proteins (HSA, IgG, and fibrinogen) and leakage of encapsulated drug doxorubicin-hydrochloride from liposomes, significantly improved uptake efficiency in HCT116 colon cancer cells, improved HCT116 tumor accumulation, and reduced distribution in normal organs (e.g., liver, spleen, lung, etc.). We demonstrate that ECM-targeting liposomes overcome the limitations of conventional liposomes and stealth liposomes in cancer therapy.

原文English
頁(從 - 到)4364-4372
頁數9
期刊Chemistry of Materials
25
發行號21
DOIs
出版狀態Published - 12 11月 2013

指紋

深入研究「Polymer-liposome complexes with a functional hydrogen-bond cross-linker for preventing protein adsorption and improving tumor accumulation」主題。共同形成了獨特的指紋。

引用此