Photopatternable Biodegradable Aliphatic Polyester with Pendent Benzophenone Groups

Dayong Chen, Chia Chih Chang, Beth Cooper, Angela Silvers, Todd Emrick*, Ryan C. Hayward

*此作品的通信作者

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Highly efficient photo-cross-linking reactions enable numerous applications in biomaterials. Here, a photopatternable biodegradable aliphatic polyester with benzophenone pendent groups was synthesized by copper-catalyzed alkyne-azide cycloaddition, affording polyesters that undergo UV-induced cross-linking to yield photopatterned films. Using this material, a self-folding multilayer structure containing polyester/hydrogel bilayer hinges was fabricated. Upon swelling of the hydrogel layer, the construct folds into a triangular tube, which subsequently unfolds due to lipase-catalyzed degradation of the polyester layer. The ability to precisely design such degradation-induced structural changes offers potential for biomaterials and medical applications, such as evolving and responsive 2D and 3D tissue engineering scaffolds.

原文English
頁(從 - 到)3329-3335
頁數7
期刊Biomacromolecules
16
發行號10
DOIs
出版狀態Published - 12 10月 2015

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