@article{b4313b375a7d4f1c887868bfad77a6a8,
title = "Phostensin caps to the pointed end of actin filaments and modulates actin dynamics",
abstract = "Phostensin, a protein phosphatase 1 F-actin cytoskeleton targeting subunit encoded by KIAA1949, consists of 165 amino acids and is located between HLA-C and HLA-E gene clusters on human chromosome 6. In this current study, we characterized the biochemical functions of phostensin. Actin dynamics assays using gelsolin-actin seeds showed that phostensin decreases the elongation and depolymerization rates of actin filament pointed ends. The feature of phostensin that binds to the pointed ends of actin filaments was observed through fluorescent single filament binding assay. Taken together, our results suggested that phostensin is an actin filament pointed end-capping protein that is capable of modulating actin dynamics.",
keywords = "Actin filament, KIAA1949, Phostensin, Protein phosphatase 1, Tropomodulin",
author = "Lai, {Ning Sheng} and Wang, {Tzu Fan} and Wang, {Shiu Lan} and Chen, {Chun Yu} and Yen, {Jia yi} and Huang, {Hsien lu} and Chin Li and Huang, {Kuang Yung} and Liu, {Su Qin} and Lin, {Ta Hsien} and Huang, {Hsien bin}",
note = "Funding Information: This work was support by grants from the National Science Council, ROC (NSC 96-2320-B-194-005-MY3, NSC 95-2320-B-194-005 and NSC 92-2311-B-010-003), the Taipei Veterans General Hospital, Taiwan, ROC (V95S4-007 and V96S4-002) and the DaLin Tzu Chi Buddhist Hospital (DTCRD95(2)-16 and DTCRD95(2)-17).",
year = "2009",
month = oct,
day = "2",
doi = "10.1016/j.bbrc.2009.07.086",
language = "English",
volume = "387",
pages = "676--681",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "4",
}