The 8 mol% yttria-stabilized zirconia (8Y-ZrO2) was bonded to stainless steel 316L at 900 °C for 1 h in a protective Ar atmosphere using an interlayer of Ti/Ni/Ti. Interfacial microstructures were characterized using both secondary electron microscope (SEM) and transmission electron microscope (TEM), each with an attached energy dispersive spectroscope (EDS). A layer sequence of σ-phase/TiFe2/TiFe + β-Ti/Ti2Fe was observed at the stainless steel 316L/Ti interface, whereas a layer sequence of Ti2Ni/Ti2Ni+ TiNi/TiNi3 was found at the Ti/Ni interface. Furthermore, TiO and c-ZrO2-x formed at the Ti/8Y-ZrO2 interface. An acicular α-Ti and a fine ω-phase existed along with β-Ti in the residual Ti foil adjacent to the stainless steel 316L, but α-Ti and Ti2Ni were observed within β-Ti in the other residual Ti foil adjacent to the 8Y-ZrO2. The orientation relationships of the ω-phase and β-Ti were [1 10β-Ti[1 210]ωand(111β-Ti(0001ω, respectively. The microstructural development was elucidated with the aid of Fe-Ti and Ni-Ti binary phase diagrams.