Pharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L.

Keyphrases

• Pharmacokinetics 100%
• Codeine 100%
• Placental Transfer 100%
• Morphine 64%
• Fetus 35%
• Pregnant Women 17%
• Placenta 17%
• Tissue Transfer 17%
• Transfer Ratio 11%
• Biotransformation 11%
• Microdialysis 11%
• Amniotic Fluid 11%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 11%
• Pregnant Rats 11%
• Organic Cation Transporter 11%
• Metabolic Biotransformation 11%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 5%
• Concentration Ratio 5%
• Cough 5%
• Prodrug 5%
• Analgesic Effect 5%
• Alkaloids 5%
• Transfer Mechanism 5%
• Toxic Effects 5%
• Ethnopharmacological Relevance 5%
• Multiple Sites 5%
• Corticosterone 5%
• Maternal Blood 5%
• Tissue Distribution 5%
• Compartmental Model 5%
• Ultra-high Performance 5%
• Pharmacokinetic Parameters 5%
• Two-compartment Model 5%
• Diarrhea 5%
• Blood Fluid 5%
• Husk 5%
• Placental Barrier 5%
• Rapid Metabolism 5%
• Phytomedicine 5%
• Blood-placenta Barrier 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Codeine 100%
• Papaver Somniferum 100%
• Pharmacokinetics 100%
• Morphine 64%
• Morphine 3 Glucuronide 35%
• Microdialysis 11%
• Organic Cation Transporter 11%
• Analgesic Agent 5%
• Prodrug 5%
• Coughing 5%
• Corticosterone 5%
• Toxicity 5%
• Pharmacokinetic Parameter 5%
• Diarrhea 5%